This readme file was created by Minja on Apr 2022 I added file GV-K.bw.signed.bedGraph , which is produced based on GV-K.bw (bigWig containig oocyte's nucleus RNA-seq coverage data) with value counts sign changed based on genes orientation: value multiplied by +1 for positive strand -1 for negative strand 0 for unknown data (i.e. all coverge for intergenic regions removed) I used genes file GCF_000002315.4_Gallus_gallus-5.0_genomic.sorted.gff (downloaded from NCBI) which better corresponds to visual observation of TAD boundaries than other gene sets